| Nowadays interior decoration is popular; however, excessive use of decorative materials possibly induces extensive indoor environmental pollution which does harm to people's health. It is significant to study the safety of interior decorative materials. Our study establishes suitable methods to evaluate the oxidation damage and genetic toxicity of VOCs emitted from decorative materials, and to provide scientific basis for revising and perfecting the related hygienic standards of interior decoration pollution.The experimental contents and results as follows:(1) Statistical analysis was done for the rate of bone marrow cell micronucleus induced by different dose of formaldehyde .40 mice were randomly divided into 5 groups , two of which was for control , and the other three were 4 ,12 and 36 mg/m3 dose group respectively. The mice were killed after they were given inhalation exposure of formaldehyde in a peaceful environment for 4 days, 6 hours per day and then the rates of bone marrow cell micronucleus were measured. There was a significant difference between high middle dose groups and control group(P<0.05).Through statistical analysis the different dose group had significant difference(P<0.01) .Compared with negative group the Cyclophosphamide(40mg/kgBw) group had significant difference(P<0.01), and the male and female had not significant difference(P>0.05). The results showed that formaldehyde might be of mutagenesis on mice.(2) Study the oxidation damage and mutation of VOCs emitted from alkyd color lacquer and latex paint which applied static inhalation single and mixed exposed experiment. Action changes in both the period of exposure and convalescence were observed periodically. After exposed, the SOD activities of 4 organs (lung, heart, liver and kidney) were measured. The results showed ,in the 3h exposed experiment, the SOD activities in liver , lung and heart were decreased significantly(P<0.01)in the alkyd color lacquer exposed group, the SOD activities in the lung decreased significantly(P<0.01)in the latex paint exposed group; in the 30h exposed experiment, the lung and liver were decreased significantly(P<0.01)both in the alkyd color lacquer and the latex paint exposed group. But the suppression effect of SOD on kidney and heart were not obvious in two single exposed group(P>0.05). In the mixed group, the SOD activities in liver and lung were decreased significantly(P<0.01). In the three exposed groups, the alkyd color lacquer had the most negative effect, the latex paint's effect was least. Under the same exposed time and measure, the alkyd color lacquer had more significant difference than the latex paint on the LDH in the lung; the mixed group had more significant difference than the other two single exposed groups. Compared with negative group , the rates of bone marrow cell micronucleus of the alkyd color lacquer group had significant difference(P<0.01), and had not significant difference in the exposed groups. The results showed that the VOCs emitted from paints might be of mutagenesis on mice. It was suggested that alkyd color lacquer had some toxic effect and oxidation damage on mice.(3) By establishing the inhalation toxicity model of indoor decorative materials, to explore the oxidation damage and genetic toxicity of VOCs emitted from decorative materials. The results showed that the SOD activities in the lung and liver were decreased significantly(P<0.01). But the suppression effect of SOD on kidney and heart was not obvious difference in the exposed group(P>0.05). The LDH activities in the lung were increased significantly(P<0.01). Compared with negative group , the rates of bone marrow cell micronucleus of the exposed group had significant difference(P<0.01).The DNA damage in peripheral blood lymphocytes of exposed mice was significantly higher than those of the negative control group (P<0.001) . The DNA damage was existed in the peripheral blood lymphocytes of mice exposed to the VOCs emitted from decorative materials.
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