Synthesis And Application Of AIE Molecular Functionalized Nanoparticles

Coordination nanoparticles are nanomaterials formed by metal ions (or clusters) with organic bridging ligands. Due to their fluorescent property, aggregation-induced emission molecules become a hot topic in analytical chemistry recently. It is reported that nanomaterials can sever as the aggregation matrix of AIE molecules to form the novel AIE aggregates with unique function. The development of novel AIE aggregates is one of the important contents for AIE researches.Based on the adjustable properties of coordination nanomaterials, this paper has developed a novel AIE aggregates with coordination nanomaterials as aggregation matrix. Furthermore, we have applied such AIE aggregates to the field of analytical detection.Firstly, a new style coordination nanoparticle was sythesised and applied to phosphate detection. The CNPs were facilely prepared by self-assembly process, simultaneously enfolding fluorophores and quenchers in CNPs. After the recognition-driven disassembly of phosphate ions, the fluorescence signals enhanced. On the basis of that, a novel turn-on fluorescent probe for the determination of phosphate ions has been designed and applied in the detection of phosphate ions in human serum samples.Secondly, a novel dual emission pH-sensitive AIE molecule was sythesised and used in intracellular pH and tumor tissue imaging, (4,4’-(hydrazine-1,2-diylidene bis (methanylylidene)) bis (3-hydroxybenzoic acid)), named HDBB. The maxium emission wavelength of HDBB was at 495 nm in weak alkaline solution, while at 590 nm in acid medium. Taking advantage of its unique properties, such as excellent cell membrane permeability, high stability and good reversibility, it has been applied for fluorescent visualization of intracellular acidity.Finally, an AIE functional CNPs were developed by using AIE molecular as organic ligands and applied for the detection of zinc ions. The results showed that HDBB can coordinate with Zn2+, Tb3+to form CNPs (Tb-HDBB-CNPs, Zn-HDBB-CNPs) respectively. Tb-HDBB-CNPs showed AIE fluorescence property of HDBB with maxium emission wavelength at 590 nm, while the one of Zn-HDBB-CNPs was at 470 nm. Based on the ions exchange effect, Tb-HDBB-CNPs can be applied to the detection of znic ions in the aqueous solution.