Preparation And Application Of Monodisperse Magnetic Mesoporous Bioactive Glass Microspheres And Its Polymer Composite Microspheres

In this work, monodisperse magnetic mesoporous bioactive glass/polymer composite microspheres were synthesized by using a three dimensional ordered macroporous carbon templates combining with a block copolymer template and sol-gel process. The potential application of the MMBGMs/polymer in targeted drug delivery system was investigated. Carbon templates with well tailored structure were replicated from silica colloidal crystal templates; the MMBGMs size could be well controlled; the stealth property of the MMBGMs/polymer composite microspheres to macrophage and the loading and release behavior of different drugs in the microspheres were investigated. Firstly, an inorganic anti-cancer drug As2O3 was loaded into the 75S25C-MMBGMs through a wet-impregnated method; 75S25C-MMBGMs were modified with PEG and PLA-PEG; the morphological features and microstructures of the drug loaded MMBGMs were characterized with TEM, XRD and small angle X-ray scatterometer; the mass of PEG modified onto the surface of MMBGMs were detected by thermal gravimetric analysis; the drug loading and release behaviour were studied by an inductively coupled plasma emission spectrometry (ICP). The results indicated that MMBGMs could load As2O3 efficiently; MMBGMs/PEG and MMBGM/s-PLA-PEG composites could evidently suppress drug release. Secondly, we also studied loading and controlled release behaviour of MMBGs-PEG and MMBGs-PLA-PEG composite microspheres for organic anti-cancer drug anastrozole and anti-inflammatory drug ibuprofen in vitro. The results showed MMBGMs/PEG and MMBGMs/PLA-PEG possessed more promising drug loading and controlled release property for organic drugs than As2O3. Thirdly, the biocompatibility and stealth property of MMBGMs/PEG and MMBGMs/PLA-PEG to macrophage were confirmed in vitro. Finally, in order to expand the applications of MMBGMs/PEG and MMBGs/PLA-PEG composite microspheres in industry, we incorporated ibuprofen loaded the composite microspheres into a toothpaste to investigate the feasibility and practicality of designing an anti-inflammatory oothpaste. All the results suggested that MMBGMs/PEG and MMBGMs/PLA-PEG have potential for industrialization and could be promising candidates for drug delivery system.