Synthesis Of 1,2,3-trisubstituted 1H-Indenes Via FeCl₃-catalyzed

In this paper, the synthesis methods of indenes, and the application of iron-catalyst were introduced, the synthesis methods of 1,2,3-trisubstituted 1H-indenes through iron-catalyed were researched. Expounded in this article is divided into three chapters, which are summarized as follows:1. Indene derivatives are very attractive and important natural products, drug candidates, pesticides, dyes, household chemical products and so on. Consequently, a number of synthetic approaches toward the construction of indene frameworks have been developed, such as the reduction/dehydration of indanone, Br(?)nsted or Lewis acids-catalyzed, iodonium-promoted, or the ring-expansion of suitably substituted cyclopropenes and transition metal- catalyzed. Although these classical methods are effective for the synthesis of indenes, several of them have several drawbacks in terms of different reaction conditions, for example, long reaction sequences, high toxicity, strong acidic conditions, use of expensive transition metals, limited methods for the preparation of starting substrates, less tolerance for sensitive organic functionalities and bad stereoselective.2. The iron salts have attracted much attention as alternative and promising catalysts for many chemical transformations because of their ready availability, low price and environmentally friendly characters. C-C bond formations by using iron salts have attracted much attention. The second Chapter introduces the development of C-C bond formations by using iron salts.3. Synthesis and characterization of 1,2,3-trisubstituted 1H-indenes through iron-catalyed. A novel and efficient method of construction of 1,2,3-trisubstituted 1H-indenes had been found. A novel intermolecular sequential two C-C bond formation and cyclization of benzylic alcohols and internal alkynes was developed with the inexpensive, non-toxic, FeCl3 catalyst in DCE. The product indenes had been characterized.