Studies Of Synthesis And Properties Of 2, 4-di-2-(5-methoxythiazolyl) Pyridine

Supramolecular chemistry is developed rapidly and applied widely in recent years as a new cross-disciplinary science. As the core content of supramolecular chemistry, studies on molecular recognition has important application value practical significance. Molecular recognition, which was already known for a long time, was at first found in the studies of enzyme-catalyzed reaction by biochemists. At first, it was used to describe effective and selective biological functions. Now, molecular recognition has been widely applied in specific functions and the process among molecules. Such processes are genealy accompanied with optical properties and conformation of electrical, chemical changes, etc. The changes indicate that it develops variations in acquisition, handle, transmission, holding of chemical informations. The molecular events that occurred in the molecular recognition must perceive physical signals, which could be detected by means of the corresponding technical means. Recognition of events is also expressed by molecular devices in the form of light.Fluorescent molecular sensors can convert molecular recognition informations into fluorescent signals, which have distinct advantages in sensitivity, selectivity, in vivo and real time detection. So fluorescent sensors have been widely applied in the analysis of cations (such as Ca2+, Mg2+, Cd2+ and so on), anions (such as F", H2PO4- and so on), neutral molecules (such as HClO and so on),and gas (such as NO and so on). Therefore fluorescent molecular sensors are widely used in environment analysis, biochemistry diagnosis, analytical chemistry and biochemistry and so on.In the thesis,2,4-di-2-(5-methoxythiazolyl) pyridine (MTP), was designed and synthesized. Meanwhile fluorescence properties of this compound have been studied. It is found that MTP is sensitive to Ag+with high selectivity. Results also show that fluorescence spectrum exhibites a red shift with the decrease of pH.So MTP could also serve as a ratiometric pH sensor.1,4-di-[4-ferrocenyl-2-(4-pyridyl) thiazolyl] benzene (DFPT) was also designed and synthesized and discussed the interaction of 4-Ferrocenyl-2-(4-pyridinyl) thiazole (4-FPT) and 1,4-di-[4-ferrocenyl-2-(4-pyridyl) thiazolyl] benzene (DFPT) with diffirent reactive oxygen species (ROS). It is found that 4-FPT and DFPT can only respond to the hypochlorous acid in the pH 7.0 medium, which is featured by a significant fluorescence enhancement. Both 4-FPT and DFPT are thus suggested as fluorescent molecular probes of HOCl.