Three-Component Reactions For Concise Synthesis Of 1,2-Dihydroisoquinolines And Synthesis Of Anti-blood Drug Prasugrel

Tandem reactions/multi-component reactions (MCRs) are operatively simple, highly efficient, convergent and atom-economic. Tandem reactions/MCRs in diazo chemistry have mainly focused on the 1,3-dipolar cycloaddition reaction of imine ylide and carbonyl ylide. Our group discovered a new series of multi-component reactions involving ammonium/hydroxyl onium ylide.The thesis mainly reported the three-component reaction of active ylide with 2-alkynylarylaldimines catalized by lewis acid which provide a green simple and efficient way for the synthesis of new complex structure of dihydro isoquinoline.The rearch discoved AgOTf as the best lewis acid together with Rh2(OAc)4, which is effective for a tandem cycliaztion/three-component reactions of 2-alkynylarylaldimines, diazo compounds and water or alcohols to afford new complex and highly functionalized 1,2-dihydroisoquinolines with adjacent a-hydroxy-β-amino carboxyl skeleton structures in one step in good to yield(yield up to 93%), but poor diastereoselectivity(50:50