Study On The Immobilization Of Lipase By Micro Capsule And Resolution Chiral Amine

The this paper carried on the biological lipase chiral resolution domain has been the exploration. In nowadays, the traditional achiral compound already could not satisfy people's needs in life and production, what is following has the chiral characteristic new compound is playing more and more important role in people's reality.Just like in the my paper said that even some compound has the chiral characteristic, but if two kinds of chiral configuration mixes together, even causes to present the racemization , also this product reality using value will possibly have a big reduction, because, just because the chiral unique characteristic, one kind of configuration will be beneficial in people's application, but another kind will be just the opposite, will not have any role, even will suppresses the beneficial configuration. At the same time, in synthesizes sole configuration in the product in the process, if from beginning stressed that the configuration uniqueness, the production cost often will enhanced, will not favor the practical application. Therefore, the chiral resolution play very important role.But in chiral resolution's all methods, said relatively that the biological zymology resolution law is one kind both are beneficial in the environmental protection and has the method highly effective merit, is analyzed the worker by the chiral to think that most has the bright prospect method.Certainly because the enzyme resolution also has certain flaw, for instance, resolution continuity, as well as, if is unable to recycle the use, causes the production cost greatly expensively by the enzyme construction cost and so on shortcomings, therefore the fossilization enzyme technology arises at the historic moment, this kind of technology may the very good solution above flaw.In my paper considers the use emphatically"the oil pocket water"the micro capsule fixed water-soluble lipase, After fossilization completion of work, has carried on the chiral resolution practical application.Resolution substrate : 2-(2, 6-dimethyl-phenyl) alanine.It is the important intermediate of Metalaxyl, which is synthesized. but effective component is the R- isomer. In the paper analyzes raceme to produce R-2-(2,6- dimethyl benzyl) propionic acid using the lipase.But because this method has used the massive organic solvents, the lipase activeness to come under the influence, then has affected the chiral resolution conversion rate. Later work:first, selects other to form the membrane the method, so ,selects the small harm the organic solvent; Second, inspects other fossilization way, For instance, Gelatin law.