Synthesis, Charactered And Properties Research Of The 1, 3, 4-Thiadiazole Thioacetanilide Derivatives

This paper includes four chapters:Chapter One: A brief review for the research of 1,3,4-thiadiazole derivatives in recent years.This chapter is a brief review for the research, synthesis methods and application values of 1,3,4-thiadiazole derivatives in recent years.There are many synthesis methods of 1,3,4-thiadiazoles and their heterocyclic derivatives; Because of their special configuration, 1,3,4-thiadiazoles and their heterocyclic derivatives have a wide range of applications in the areas of agricultural, medicinal chemistry, industrialand and other fields. And arousing great interesting to more and more scientists.Chapter Two: A novel derivatives of [5-(arylmethylideneamino)-1,3,4-thiadiazol -2-yl] thioacetanilide were synthesized by the reaction of S-alkylation of 5-arylmethylideneamino-2-mercapto-1,3,4-thiadiazole with chloroacetanilides under the conditions of solid-liquid phase transfer catalysis using PEG-400 as a phase transfer catalyst in the presence of potassium carbonate. All the products were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectra.Chapter Three: The preliminary biological activity tests showed that some of the title compounds had obvious regulating activities for the growth of wheat, barley and rape seeds, and some compounds such as 4a and 4e possessed satisfactory activity of growth inhibition against B.subtilis at a test concentration (20 mg/mL).Chapter Four: Three anion sensors bearing heterocyclic NH were synthesized and the anion recognition research were taken by UV-vis spectra. The result indicated that the affinity is related to the space frame of the binding group. The receptor 1, 3 can act as F-,AcO- and H2PO4- anions sensor by naked eye.