Preparation And Research Of Copolymer Polymerized With Silk Fibroin And Oligomer L-lactic Acid

Poly L-lactic acid (PLLA) as the biodegradable polymer materials can be used for human, but it can result in moderate inflammation if implanted in bodies. Silk fibroin (SF) can improve the bioco MPatibility of PLLA. The study on the melt copolymerization of PLLA with silk fibroin has not reported yet.In this paper, L-lactic acid(LLA) and SF were polymerized through melt copolycondesation with Tin salt / proton acid as the catalyst system. Polarimety, FT-IR,DSC, 1H-NMR, 13C-NMR, XRD, scanning electron microscopy, and TEM were used to detect microstructure, molecular weight, and optical purity of poly(lactic acid-co-silk fibroin) (PSFLA) samples. The effects of reaction conditions on PSFLA were analyzed, which included reaction time, temperature, amount of catalysts, and mass ratio of raw materials.Optical purity and molecular weight of copolymerwere changed with reaction conditions, with SnCl2/p-toluenesulfonic acid and Sn(Oct)2/p-toluenesulfonic acid as catalyst systems.In a word, LLA and SF were polymerized through melt copolycondesation with Tin salt / proton acid as catalyst systems to prepare copolymers, which can reduce environmental pollution and the cost of PSFLA copolymers. The resources of silk fibroin and lactic acid are abundant in our country, so the research on copolymers of SF with PLLA has tremendous economic and social benefits.