Studies On The Preparation Process And Quality Criteria Of Jingmen Shangqingwan

Jingmen shang qing wan is from Jingmen Pill Lee"old plot Yam Tong"family′s secret,composed of Catechu,musk,mint, Nepeta,Campanulaceae,tonkinensis,borneol,borax,Huanglian, licorice flavor,with the efficacy of heat-clearing and detoxifying.Indications:dizziness,headache,modification headache,tinnitus and deafness,ear pain,head red storm red, dizzy rotten tears,throat tongue sores,sore gums bleeding, swollen nasal plugs,nasal sores,Wind hot cough,cold heat stroke,etc.In the whole process,we do not change the original form of the premise,made the extraction process and molding process,the quality of the research component of the quality standards for intermediate inspection and finished products,results show that the quality is stable and controllable.1,All the material in the experiment carried out with medicinal fate-based identification,control indicator composition containing the determination of the ingredients,all medicines are in line with the Chinese Pharmacopoeia 2005 edition's relevant requirements.2,preparation of the research(1) Extraction Process:We studied the added water and the extraction time when extract volatile oil from Schizonepeta and mint,the results is the use of add 10 times the volume of water, and extracted five hours.Dregs and the rest of Huanglian, tonkinensis,Licorice,Platycodon was studied the water extraction,extract the number,extraction time,added water, the three factors,the final optimization of extraction process of selection,extract three times,add 10 times water,each extraction 2 hours.Experience in certification testing and test amplification,the extraction process is stable and feasible.(2) Molding Process:In accordance with Chinese medicine Preparation of the technical requirements for the forming process of the study,the use of pan-Honmaru Ways,study the Pan-humidity environment,ethanol concentration and drying temperature,the results of environmental humidity should be controlled at relative humidity below 60%,using 95%ethanol dissolved volatile oil for the adhesive,the drying temperature should be controlled at below 40℃。3,intermediate quality standardsNepeta(1000g),menthol(1000g) add 10 times the volume of water, boiled 5 hours,the collection of volatile oi 1,filtrate Save, dregs and Licorice(140g),Campanulaceae(1000g),berberine (100g),tonkinensis(300g) mixing,add water extract three times a 10-fold increase in the volume of water,extracted two hours,boiling water solution,while it is hot filtration,the filtrate three times merged with the mint,mixed with Schizonepeta filtrate concentrated into extract,80℃bake Do, do have to extract,crush over 120 mesh,may do extract powder. Dry extract and the extraction of berberine hydrochloride is in the control of the volume indicator,stability, controllability and repeatability.4,product quality standardsWe studied the Jingmen shangqingwan's quality standards, according to the Pharmacopoeia general items to check. Including moisture,the weight differences,differences in quantity,the time limit bulk dissolved,heavy metals,arsenic salts,the results are in line with the Pharmacopoeia.Test used to identify each other in the thin-layer chromatography Catechu, Nepeta,mint,borneol,etc.Have been studied separately, inorganic category belong to one of borax,a chemical reaction authentication,and set up a Catechu,mint,Nepeta,Borneol TLC method,and set up using gas chromatography for the qualitative identification of musk,content was determined by high performance liquid chromatography for the goods in catechin, epicatechin were determined.