Studies On The Synthesis Of Amides

This thesis is concerned with the studies on the preparation of amides with good biological activity and medicinal value.It mainly consists of the following three parts:In chapter 1,a concise review about the recent progress made on the synthesis of amides is described.Chapter 2 was mainly focused on the synthetic methodology based on Hantzsch ester,a NADH model compound;then,the study on the synthesis of benzamides was introduced in detail.The selective reduction of the alkoxy was achieved by using Hantzsch ester 1,4-dihydropyridine as the reducing agent in toluene.This method has a moderate reduction,clean and efficient advantages.In chapter 3,the study on the synthesis of symmetrical N,N'-alkylidene bisamides was introduced in detail.After scanning a variety of lewis acid such as AlCl₃,FeCl₃, FeCl₂,CuCl,CrCl₃,CoCl₂,FeSO₄ and so on,we found aldehydes and amides can be efficiently transformed to symmetrical N,N'-alkylidene bisamides in the precence of catalytic ZnCl₂.The reaction expanded the application of ZnCl₂ in organic synthesis. In addition,this procedure has some advantages in competition with the previously reported methods,such as good to excellent yields of products,short reaction times, low toxicity,low cost,a commercially available catalyst,and simplicity of work-up.