| Recently, organic-inorganic hybrid film has been more and more focused because of the dual advantages inherent from both organic and inorganic films; however, there is no report in medical field. In this work, the skin compatible hydrophilic organic- inorganic hybrid films were studied. Two film-forming systems were synthesized and characterized in order to develop novel convenient and comfortable transdermal drug delivery systems.Two kinds of silane coupling agents (tetraethoxysilane, short for TEOS; andγ-glycidyloxypropyltrimethoxysilane, GPTMS) were used to get chemical crosslinks in poly(vinyl alcohol) solution, to form spatial network configuration. FTIR, SEM and DSC ect.were used to characterize the hybrid films. The mechanical properties and swelling properties of hybrid films were investigated in order to analyse the role of silane coupling agents in hybrid films systematically. The films formation on human arms, water vapor permeation and skin irration test on white rabbits were also conducted to review the comfortability and irration reaction. In vivo drug release experiement was performed on skin incised wounds of white rabbits to study the curative effect of transdermal film preparations. In vitro drug delivery properties of hybrid films were investigated detailedly by using different drugs and drug-loadens, in order to study the influence of interactions between drugs and matrix to release properties. The stability of films was also studies to estimate the half life of drugs and period of validity of the film preparation.
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