The Research On Preparation And Propertiesof A Novel Copper-containing Conceptive Composite

As far as traditional metallic copper contraception device concerned, there existed side- effects such as abnormal bleeding, pain, partial and complete expulsion associated with the burst release of cupric ions in the first few days. What is more, the cupric ions trapped in the corrosion product and deposited was about 30-40% of the total copper ions released, indicating that one-third of the copper released is ineffective from the contraceptive viewpoint. These depositions could also result in some side effects during the corrosion of copper in uterine solution. In this paper, to overcome these limitations, a novel controllable copper containing composites with polymer substrate was investigated, its related properties studied as well.Firstly, silica sol was employed to modify the poly (vinyl alcohol) (PVA). Specifically speaking, various content of silica was added into PVA solution. It was then heated to obtain a homogeneous solution. Subsequently, it was poured in to a slide and clean glass plates. After dried at room temperature, the structure, thermal properties, crystallinity, surface morphology, mechanical properties as well as solubility were studied by IR, DSC, TG, SEM, XRD and electro-tensile testing machine. With these methods of characterization, PVA with twenty percent of silica was selected as the substrate of the controllable material.Secondly, different copper chloride and ammonium oxalate contend were added into the above composites, and its pertinent properties were studied. To ensure the composites with excellent mechanical properties, proper aperture size as well as copper content, four percent copper chloride and two percent ammonium oxalate were finally selected as the controllable biomaterial.Finally, the release rate of cupric ions of the 20%SiO₂/4%CuCl₂/2% (COONH4)₂/PVA composite in simulated body fluid (SBF) was investigated by atomic absorption spectrophotometer. The structure, thermal properties, crystallinity, mechanical properties and surface element after soaking in SBF for different time span was studied as well.In conclusion, the above-mentioned results indicated that the tensile strength and the solubility of PVA were improved significantly by the addition of silica sol. The reinforcement of PVA modified with silica sol is much better than that filled with nano-silica power. Furthermore, the burst release of cupric ions in SBF is absence in this novel prepared controllable copper-containing composite, indicating that the side effects caused by the bust release of copper could be eliminated. Meanwhile, cupric oxide, calcium and phosphorus did not appear in the surface of the composite after soaking in SBF, indicating that nearly all copper loaded in the composites could be translate into cupric ion. Therefore, to a large extend, this novel copper containing composite with polymer substrates could overcome the disadvantages caused by traditional copper.