Synthesis And Characterization Of Three Novel Degradable Electrically Conducting Copolymer

Three novel degradable electrically conducting copolymers which are electro-active,remarkably biodegradable were synthesized.Firstly electrically conducting polymers(carboxyl-capped aniline pentamer,poly(indole-5-carboxylic acid)(PICA)) and degradable polymers(hydroxyl-capped polyglycolide(PGA), phthalylchitosan(PHCS)) were synthesized.Then the degradable electrically conducting copolymers were prepared by low-temperature polycondensation between electrically conducting polymers and degradable polymers,with N, N'-dicyclohexylcarbodiimide(DCC) as dehydrating agent and 4-dimethylaminopyridine(DMAP) as catalyst.The structure and morphology of the copolymer of aniline pentamer and PGA were characterized by IR,¹H NMR and SEM.The redox process was checked by cyclic voltammetry(CV) and UV-vis spectra.Moreover,the thermal stability was studied by TG-DTG analysis.The electrical conductivity of the copolymer measured is in the semiconducting region,which can be used as semiconducting material.The degradable experiment in simulating humoral environment proved that this electrically conducting polymer containing degradable segment has good degradability.The structure and morphology of the copolymer of PICA and PGA were characterized by IR,¹H NMR,UV and SEM.The optical and electrochemical properties of the copolymer were studied by fluorescence spectra and cyclic voltammetry. The electrical conductivity and degradability of the copolymer were also investigated. The biocompatibility of the copolymer was investigated with BHK₂₁ cells,the results show that the copolymer can support cell attachment and proliferation,so it has good biocompatibility. The structure and morphology of the copolymer of aniline pentamer and PHCS was characterized by IR and SEM.The optical property of the copolymer was studied by UV.The electrical conductivity and degradability.were also investigated.