Processing And Mechanism Research Of Emamectin Benzoate Micro-emulsion

Emamectin benzoate which was developed by the United States Merck was an efficient,broad-spectrum,non-pollution biological pesticide.Because of it's high activity and low preparation,Emamectin benzoate was widely used today.But the main preparation on the current market was emamectin benzoate EC,it need to consume a large amount of organic solvents,such as xylene,which was likely to lead to environmental pollution,waste of resources,and increase costs.In order to reduce environmental pollution,improve the effect of preparation and save costs,In this study,it was produced as an environment-friendly form which achieve good environment and economic benefits.The research could be summaried as followed:1.By the study,the prescription of emamectin benzoate 1%ME was filtrated and appropriate solvent and emulsifier were selected.The best solvent was the mixture of cyclohexanone and N'N-dimethylformamide(1:2,m/m),which was 15%weight of total composition;the emulsifier was a certain ratio of alkylphenols polyoxyethylene ether,styrene polyoxyethylene-phenol ethers and 500#,occupied 15%weight;the content of co-surfactant(n-octanol)was 2%weight,the other conponent was water. The factors that influence cold and hot storage stability were studied.The results showed the qualified indicators of the sample quality and the perfect adaptability of formula.2.The pseudo-ternary phase diagrams of emamectin benzoate microemulsion with four different kinds of emulsifier were plotted based on the electric conductivity.The phase diagram could support the filtration of emamectin benzoate Microemulsion surfactant and improve efficiency.ME with hydrophilic surfactants have wide transparent temperature range in high temperature area,and ME with lipophilic surfactants have wide transparent temperature range in low temperature area and good low-temperature stability.Low-temperature stability of micro-emulsion,emulsion stability and transparent temperature range were greatly influenced by Surfactant structure and the amount.Adding surfactant could improve the performances of salt-dimensional micro-emulsion.3.Study on low-temperature stability,cloud point,emulsion stability,the impact of high temperature stability of pesticide Micro-emulsion it was showed that Choosing a suitable solvent,surfactant can improve the low-temperature stability of micro-emulsion;along with the increasing of the hydrophilic surfactant-(EO),the higher cloud point was.The increasing in higher-hydrophilic surfactant was conducive to raise Micro-emulsion emulsion stability.High surfactant/water(w/w) ratio was propitious to the formation "compactly" the boundary layer which was difficult for the hydrone to penetrate,or even if it could penetrate by "the fetter" form and be existent,but it couldn't contact with the effective component of pesticide, which could assured hot storage stability.4.Study on the electrical conductivity of salt-dimensional micro-structural changes in the emulsion showed that with the addition of water,the micro-emulsion in the emulsion W/O structure,LCD,bicontinuous structure and O/W structural of salt-dimensional structure changed,which held a preliminary discussion on the mechanism.5.The qualitative and quantitative analysis method of emamectin benzoate micro-emulsion with HPLC was studied.The decomposition rate was less than 5%, which measured up to the national standards.Through determination of the indoor toxicity,the LC50 changed little after.This also showed that the preparation of hot storage stability was better...