Research Of Retention Ratio Of Salviandic Acid B And Optimization Of Preparation Technology Of Compound Danshen Tablet

Compound Danshen Tablet is a famous Chinese traditional patent medicine which can remedy cardiovascular disease seen in Chinese pharmacopoeia (2005th Edition) .It is composed of salvia, Radix notoginseng, borneol and other excipients ,and has the effect of blood-activating and stasis-eliminating, obstruction-removing and circulation-smoothing.The extraction solvent of Compound Danshen Tablet is ethanol firstly and then water, which can reserve the fat-soluble and water-soluble components. The shortcoming of the extract technique is high extract ratio and loss and Destruction of some Components such as Salviandic Acid B,which cannot bear heating and concentrating process, the extract technique can not only cause quality difference in products, but also impact the clinical effect.To observe the Salviandic Acid B retention ratio of Compound Danshen Tablet. Through the all manufacturing processes of it, we acquire the factors impact on the Salviandic Acid B retention ratio. Meanwhile, to solve the problem of instability on light and heat, we optimize the extract and process. The aim of research is to instruct the of technique manufacturing.To research of Compound Danshen Tablet from some domestic pharmaceutical factory , determine the concentration of Salviandic Acid B , calculate the retention ratio. Analyze the consequence of high difference , and Extrapolate the consequence of low retention ratio. Inspect the impact Influence factor of retention ratio systematically. According to the optimization technique, prepare 10 series products , determine the mean components , observe the Salviandic Acid B retention ratio, in contrast with the data of the current research before optimization. Ultimately , pose the choice of manufacturing process. Choosing some series products of Compound Danshen Tablet from domestic pharmaceutical factory, the quality of products are irregular and uneven. Although bulk of them is fit to the criteria of Ch.P., but the Salviandic Acid B retention ratio is a bit low. Inspect the impact Influence factor of retention ratio systematically, which comprise the identification process, extract process, concentration process, dry granulating, compression process and coating process. The important factor is extract and concentration process, and the solution is to shorten the heating time and decrease the temperature. The dryness style is by hot-wind or decompress. In the form of optimization technology, prepare 10 series products, retention ratio of Salviandic Acid B is obviously higher than the current.The research can solve the common problems of all pharmaceutical factory, encourage them to improve the current preparation technology of Compound Danshen Tablet, and has a certain of practical significance.