Preparation And Properties Of Functional Polymer Films

In the field of biomedicine, pharmaceutical biomaterial is a new developed subject in recent years. It is the development and intersectant product of modern pharmaceutics and material science. The modern pharmaceutics primarily includes controlled Drug Delivery System(DDS), targeting DDS , intelligent DDS, transdermal DDS, mucosal DDS, et al. In all these DDS, the materials (carrier) used must be particular and special. Therefore, there will be no modern dosage forms and modern pharmaceutics if there were no pharmaceutical biomaterials (especially pharmaceutical macromolecules).Polymeric materials used as the carrier in the controlled release of drugs have become an important research area in the study of polymer science. Further more, the film dosage (a new medicine dosage) has such advantages as easy preparation technology, convenient, slow release and so on. Therefore, the studies on it has been paid much attention. Thus, it has expansive foregrounds of the research of new biocompatible biomaterials. According to the blends of two polymers, we chose Poly(vinyl alcohol ) (PVA) as the film matrix because of its good capability to make film. PVA gel has been widely used as the carrier of medicine release because of its hydrophilic ability, bio-degradability, nontoxicity and so on. And as the medicine carrier, it has good campatibilty with other medicine and bio-compounds, so that it can be widely used as carrier for medicine. Furthermore, it provides good dispersion and coating properties as film material.Depending on the design of molecule, we chose proper modification reagent. And after the study of the main factors, such as the dosage of modification reagent, catalyzer, temperature and reaction time of the system, we devised the modification conditions of PVA to make quickly water-soluble film. And the films which is quickly water-soluble (the soluble time is 75s) and has good mechanical properties (the max tensile stress is 29.82Mpa and the tensile strain is 330.97%) were prepared and characterized. After that, the films loaded with different dosage of medicine were prepared. At last, we studied the films' solubility, medicine release, mechanical properties, stability, thermal stability, et al. Which indicates that all the above properties are very good.In addition, owing to its nontoxic, biocompatible, biodegradable and antibacterial properties, chitosan and its derivatives have attracted great interest in various fields, especially in environmental protection and biomedical engineering. Similarly, previous results have shown that CNTs has good adsorptive properties so as to be widely used in the field of environment protection and medicine, which may be attributed to the unique structure and properties of the CNTs. However, the application of chitosan has been limited because of its mechanical properties. After the treatments of the raw MWNTs by ball milting, purification and strong acid treatment, we prepared the MWNTs/chitosan nanocomposites films, and the films mechanical properties has been primarily studied. It shows that the max tensile stress of MWNTs/chitosan nanocomposites is more better than the chitosan film. But the tensile strain has been declined. In order to conquer the disadvantage, we synthesized the Covalent Functionalization of MWNTs with low molecular weight chitosan (LMCS) in order to prepare films with more better mechanical properties. After the characterization of FTIR, solid states magic angle spinning ¹³C NMR, ¹H NMR, TEM, and so on, we educed that the covalent bond has been formed.The study of all these functional film materials have great academic significance and application foreground on the interaction study of chemistry,life sciences and material sciences. And what's more, the exploitation of the new film materials has social benefits and expansive progress in the market.