Synthesis, Assembly Of Amphiphilic Copolymer Containing Poly [2-(Dimethylamino) Ethylmethacrylate]

Stimuli-responsive amphiphilic block copolymers have drawn much attention due to their various promising potential applications. The pH and temperature responsive block copolymers are considerably important because they are relatively convenient to be synthesized and sensitive to outer stimuli. Poly[2-(Dimethylamino) -ethylmethacrylate] (PDMAEMA) is a classical pH and temperature responsive macromolecular material.In Chapter Two, we described the synthesis and characterization of the amphiphilic copolymer poly (methylmethacrylate)-block- poly [2-(Dimethylamino) -ethylmethacrylate] (PMMA-b-PDMAEMA), and investigated the self-assembly behavior of this novel block copolymer PMMA-b-PDMAEMA. Because of the protonize in acidic solution, the PDMAEMA chain is hydrophilic. Thus, we obtained the micelle, which has PMMA core and PDMAEMA shell in acidic solution. The concentration influences the size of micelle.In Chapter Three, we described the synthesis and characterization of the amphiphilic triblock polymer poly [2-(Dimethylamino)ethylmethacrylate]-block- Poly (ethylene glycol)-block- poly [2-(Dimethylamino)ethylmethacrylate] (PMMA-b-PDMAEMA). We investigated the pH and temperature responsive of this triblock copolymer. We found that the LCST is related to concentration and pH value. Furthermore, the size of micelle aggregate is determined upon concentration and pH value. Then we used the triblock polymer to improve the water-solubility of Fe3O4 nanoparticular.In summary, we synthesized two novel amphiphilic block polymer, which contain PDMAEMA chain. They are stimuli- responsible. We can control size of the aggregate through change pH or temperature. We anticipate that these pH/temperature responsive micelle can be exploited for biomedicine.