The Syntheses Of One Novel Anti-viral Drug Famciclovir And Its Intermediate Derivatives

The purines'nucleoside compounds are broad-spectrum antiviral agent. In the thesis, We have reviewed extensively based on the detailed investigation of the related litertures,Our work was carried out as followed: On one of the high efficiency, low toxicity of anti-herpes virus nucleoside compounds Famciclovir the Synthesis Process Optimization improvement. We will discussed mainly the synthesis of famciclovir which is one of the purines' nucleoside compounds. The famciclovir was synthesized from purine by a series of steps by Acylation, Decarboxylation, Reduction ,and so on; Derivatives of these intermediates is described from the 6-chloro- 9H- purin-2-amine as raw materials in different conditions when the iodine and bromide were synthesized with the addition of two intermediate 6-bromo-9H-purin-2-amine and 6-iodo-9H-purin-2-amine; There is elaborated from the main part of a acetophenone, urineaminohydrochloride, phenylhydrazine, ethyl acetoacetate as raw material through a series of reactions to synthetic 3-phenyl-4-formylphenyl pyrazole and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-aldehyde two pyrazole aldehyde, and then with 2-amino-6-chlorine-9-(2-methicillin-oxo-co-methyl-4-yl) purine reaction of the two new pyrazole purine Schiff bases.