The Synthesis And Studies Of Series Aromatic Nucleus Derivational Medicine Intermediate

As the human living standard enhances unceasingly, people pays more and more attention to its own health. In order to conquer disease, the scientists pay more and more attention to develop new medicines. And the new medicine intermediate is the key of developing new medicines. So, the medicine intermediates, as an important profession in medical fine chemical domain, have already became various countries' developing and compositional focal point in the recent ten years.Certain medicine intermediates including the aromatic nucleus derivative have the extremely good application prospect in synthesis Diabetes's Occurement medicine and Schizophrenia medicine etc, they are always hot researching spot in various countries. The present paper did research in synthesis medicine intermediates of inhibitor of Glycogen synthase kinase-3 and 5-hydroxytryptamine 2A, series of contained fluorine pyridine class intermediate.1,the experiment datum indicated it, Glycogen synthase kinase-3( GSK-3)played a important role in the process of type 2 Diabetes's Occurement development, so to find a suitable GSK-3 inhibitor, it should be a potential drug to type 2 Diabetes's therapy. This paper synthesized two intermediate of the inhibitor: 6,7,8,9-Tetrahydro -5H-pyrido[2,3-b]azepine- 5,8-dione and 1H-Pyrido[3,4-b]-azepine-2,5(3H,4H)-dione, then characterized them;2,5-hydroxytryptamine 2A(5-HT 2A) has Already been confirmed for the schizophrenia candidate easy feeling gene, so the 5-HT 2A inhibitor should be a potential drug for Anti-neurosis, this paper synthesized three intermediate of the inhibitor, and characterized them;3,with the weak basicity, The pyridine linked the nitrogen atom whose electro negativity is strong, then introduced the strong negativity fluorine atom, The synthesized pyridine derivatives including fluorine has brought to chemist's attention because of its special function and the biological activity, and its medicine intermediate displays quite outstanding in the medicine performance, so the fluorine pyridine class intermediate will become to contained fluorine intermediate research and development main directions in our domestic the next several years. This paper synthesized a series of contained fluorine pyridine class intermediate embarked from 2- amino - 4- methyl pyridine, and characterized them.