| The structures of macrocyclic ligands and their complexes are similar with thoseof some important bioenzymes in body, which are hopeful in the biomimeticchemistry and the biological medicine, the metal enzyme simulation, cell membranetransmission and self-assembly of supramolecular and so on has its vitalsignificance. The development of macrocyclic coordination chemistry has closerelationship with the progress of synthesis methods. Now the way to preparemacrocyclic complexes includes direct synthesis methods, template methods.DNA in the organism is an important kind of macro-molecule, its biologicfunction relies on its physicical and the chemical reaction with little metalcoordination complexes in the body, during past 10 years, the research which mutuallyaffected to the transition metal organic coordination and DNA has been an extremelyactive domain.The first part will summarize the research history and the recent development ofthe macrocyclic crown ethers and its metals coordinated complexes, the severaltypical synthetic methods have made the brief introduction, and the meaning toresreach the macrocycles are emphasized.The second part synthesized three kind of crown ethers with direct synthesismethods. include synthesis of complexes of 5, 7, 12, 14-tetraethyl-7, 14-dimethyl-1, 4,8, 11—tetraazamacrocyclic crown ethers,5, 5, 7, 12, 12, 14-hexamethyl-1, 4, 8, 11—tetraazamacrocyclic crown ethers,5, 12—diphenyl—7, 14—dimethyl—1, 4, 8, 11—tetraazamacrocyclic crown ether and their coordinated complexes, unit crystals ofC20H46N4·2ClO4 and Cu C16H36N4·2 Ag (CN)2·2H2O have been raised successfully,also IR spectra, UV, Elemental analysis and single-crystal X-ray were used tocharacterize these complexes.In the third part, we synthesized three members supramolecular compound with1,10-phenanthrolline, phthalic acid and transition metal copper, and its unit crystal hasbeen raised successfully, also single-crystal X-ray were used to characterize itscomplex. The fourth part, we researched the catalyzed performance in the oxidation ofphenolto about copper complexes of-5, 7, 12, 14-tetraethyl-7, 14-dimethyl-1, 4, 8, 11—tetraazamacrocyclic crown ethers and -5, 5, 7, 12, 12, 14-hexamethyl-1, 4, 8, 11—tetraazamacrocyclic crown ethers with the chromatograph analysis method, and alsodid the research on high potential catalytic activity, a conclusion can be drawed thatcrown ether coordinated complexes have catalytic activity to the phenol hydroxylatingand also display a certain catalyzed selectivity, its catalyzed mechanism still inexploration.The fifth part, we has studied electrochemistry performance of crown etherand its electrochemistry change with DNA. So that the people can understoodthe biological phenomena in the essence from the molecular level, then seeks aneffective medicine to treatment people through molecular design in a new way. |
