Catalytic Activation Of N-H, C-H Bond And Their Reactions With Olefins

In this thesis, we described two types of atom economic reactions: transition metal catalyzed C-N coupling reaction and C-C coupling reaction.1.Cerium(â…£) ammonium nitrate(CAN) catalyzed aza-Michael addition of amines to a,β-unsaturated electrophilesAfter we examined the reaction conditions such as the quantity of catalyst, reaction temperature and solvent. We found the reaction of amines (1.5 mmol) and a, 3-unsaturated electrophiles (1.0 mmol) proceeded well in the presence of 10 mol% CAN at 60℃. And the corresponding products were obtained in good to excellent yields. The further research revealed that the efficiency of this reaction could be improved dramatically with the ultrasound irradiation.2.FeCl₃ catalyzed addition of activated methylenes to styrene derivatives under airA simple and efficient FeCl₃-catalyzed addition of theα-C-H bond of 1, 3-dicarbonyl compounds to styrenes were developed, FeCl₃ shows high catalytic activity. Under optimized conditions, good to excellent yields were obtained.In conclusion, we have developed two environment friendly catalyst systems for atom economic transformation of N-H and C-H bond.