Synthesis Of Arenesulfonylisothiocyanates And Mondified Of Quinolone Analogues

It's well known that activities of quinoline carboxylic acid analogues to fungus andvirus are lower but thioureas are high. Thus, we imagine that by linking of the two kinds of compounds together through organic synthesis. This topic has studied synthesis condition of the use triphosgene substitution carbonyl chloride to preparation Arenesulfonylisothiocyanates, designed and synthesized a series of new compounds by the reaction between Arenesulfonylisothiocyanates and 1-alkyl-6-fluro-7-(1-piperazinyl)-1, 4-dihydro-4-oxo-quinoline-3-carb oxylic acid. Nine compounds were prepared, and them were new.This thesis consisted of three chapters.Chapter one was a review of Main introduction quinoline carboxylic acid analogues medicine structure transformation process, this kind of medicine construction effect relations. In view of the fact that the multitudinous aroyl thiourea derivative has the anti- fungus, the antivirus and the antibacterial and so on the broad spectrum biological activity. May use in the medicine design to join together the principle, by Norfloxacin and Ciprofloxacin the forerunner compound, by thefragrant sulphur acyl group sulfo- isocyanogen diethylene glycol dinitrate with promise fluorine Sha Xing, the Ciprofloxacin 7 bases responded separately strengthens this kind of compound antibacterial activeness.Chapter two was linvestigated about the clean synthesis craft of Arenesulfonylisothiocyanates, In the modified work, cleanly conveniently synthesizes the structure dressing agent Arenesulfonylisothiocyanates is the key that seeks the new antibacterial more ideal quinoline carboxylic acid analogues medicine. This topic has studied synthesis condition of the use triphosgene substitution carbonyl chloride to preparation Arenesulfonylisothiocyanates, has avoided the use extremely poisonous carbonyl chloride, eliminated in the response sulphur dioxide gas emitting, enables this craft to become to the environment quite friendly clean synthesis craft.Chapter three related mondifed of quinoline carboxylic acid analogues,...