The Synthesis Of 1, 5-Benzothiazepine, 1, 5-Benzodiazepine And Pyrazoline Derivatives Containing 2-Phenyl-1, 2, 3-triazole

1,5-Benzothiazepines and 1,5-Benzodiazepines are a kind of seven- membered ring heter- ocyclic compounds which possess many pharmacology activities and biological activities. For many years, their structure, synthetic mothods and biological activities attracted the extensive attention both at home and abroad. The ring addition reaction of the C=N double bond has caused the chemists' great interest, because this functional group carries on one of the main reactive position of chemical modification and derivatization. Therefore, we can synthesize and develop a series of the new 1,5-Benzothiazepine and 1,5-Benzodiazepine derivatives; The pyrazolline derivatives is the good materials of photoluminescence, at the same time the pyrazolline ring is the important structure unit of the pesticide whice have different biological activation too; 1,2,3-triazole ring have many pharmacology activation in itself, Therefore, we expect to realize reinforcement of many physiological activities by mean of combining the new group, 2-phyenyl-1,2,3-trizole which have strong biological activities with 1,5-Benzothiazepine and 1,5-Benzodiazepine and pyrazolline.The thesis is includes two major parts:The first part is about literature review. The important synthetic methods, the structure and chemical transformation of 1,5-Benzothiazepine and 1,5-Benzodiazepine and pyrazolline derivatives that have studied in home and other countries were explicated systematically.The second part is the experiment part, the main work as follows:1. Synthesis of 1,5-Benzothiazepine Derivatives containing 2-Phenyl-1,2,3-triazole. phenyl aldehyde (or para-substituted phenyl aldehydes) reacted with acetophenone (or para-substituted acetophenones) to form fifteen chalcones (1a~1o) by aldol condensation. The...