Studies On The Synthesis Of Melphalan

Along with the advancement of the medicine and the controlling of the universality epidempic,the malignancy has became one of the dominating and frequent ailments intimidating human being and the quality of life.The death rate ocaused by malignancy is the second among the ailments,just inferior to the heart-brain blood vessel ailment.Melphalan is a sort of chlormethine antitumor drug,which is one of the aminophenol chlormethine.It can be used to cure Brast cancer,Ovary carcinoma,Malignant lymphom (MM), Osteosarcoma , Soft tissue sarcoma(STS) and so on..Singleness or jointing with other medicine is obvious curative effect to part of the afternoon Galactophore cancer patients.Melphalan is availability to part of erythrocytosis patient.Melphalan ever used as assistant medicine to Galactophore cance in surgery. In this paper, the synthetic route which is fit for factory was selected through retro-synthetic analysis of the structure. Further more, the L-phenylalanine was chosen as the original substance. we gained the product by a series reaction,such as nitration, esterify,acyl, deoxidize, alkylation, halogenate and so on..