Synthesis Of Hydrophilicity Porphyrins And Their Metal Complexes And Their Chemical Simulation

Porphyrins are composed of methylidyne 4 pyrrole rings, their common structural features are a macro conjugated skeleton and a particular cavity resulting in special proparties. They wildly exist in natural biomass such as chlorophyll, protoheme, redamina, playing a very important role in oxygenic transfer ( hemoglobin), stockpile ( myoglobin), activation ( cytochrome P-450) and photosynthesis ( chlorophyll) etc. The study on porphyrins begined in 1930s, becoming important targets of optical conductor, semiconductor, superconductor, catalyzer, anticancer drug and developer. They have been of great importance in the fields, such as inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, materials chemistry, medicine and biology. In recent years, the in-depth research of porphyrins and their complexes focued on the active groups that were linked to porphyrins. Therefore, the synthesis of hydrophilicity porphyrins and their metal complexes appear very important.We have been devoted in the study of the metalation porphyrins, coordination chemistry for porphyrins and calixfurans. Potential enzyme model compounds were synthesized by treating porphyrins with metal ion. In addition, the characterization and catalytic activity were investigated.The research process mostly focused on seeking synthetic conditions of hydrophilicity porphyrins with hydroxyl or aminol groups and studying their sulfonating. Moreover, some kinds of porphyrins that did not reported, were obtained through acylation reaction of tetra(4- hydroxyphenyl)porphyrin and acyl chloride. The metalations of tetra(4-hydroxylphenyl)porphyrin, tetra(4-aminophenyl)porphyrin and tetra(4-hydroxyl-3-sulfonicphenyl)porphyrin with Zn²⁺,Cu²⁺,Mn²⁺,Co²⁺ were studied. The corresponding metalloporphyrins were studied also as mimic enzymes on catalytic activity.