Studies On The Synthesis Of Marine Naturally Occurring Haliclorensin

This thesis mainly contains three parts, which include total synthesis studies on the marine alkaloid Haliclorensin , studies and promoption on some reactions in some synthesis.Part â… : Chiral oxazolidinones in Asymmetric synthesisCharacteristic, synthesis and cleavage of the oxazolidinones auxiliary have been introduced in the review , which also included some successful applications in the stereoselective construction of a number of natural products. Part â…¡: Studies on the total synthesis of marine alkaloid HaliclorensinThe staring material is (L)-Phenyl alanine. Using reduction, cyclization and N-acylation , Evans auxiliary was achieved. Through condensation in the presences of LDA, deprotection , then protection of TBS and hydroboration/iodination , we obtained alkyl iodide , which a key precursor in the synthesis of Haliclorensin . Then we will try to link the chiral segment and alkyl bromide through Grinard coupling and Li₂CuCl₄. The alkyl bromide were achieved starting from 1,4-butanediol through two steps. Part â…¢: Studies of some reaction in the synthesisThe last and the most difficult processes in the synthesis of 3, 5, 7-trih ydroxy-3',4'-isopropyldioxy-flavone and FIPRONIL were studied, and we got e xcellent results. At the same time, we also made some exploration of Rotenoid and 1,3-benzodioxole.