Synthesis Of Finasteroid

Steroid hormones: finaseride is an inhibitor of 5a-redutase, which plays an important function in many androgen-sensitive tissues by converting the major circulating androgenic hormone, testosterone, into the more potent intracellular andro genic metabolite dihydrotestosterone (DHT). It is the chief pharmaceutical in the treatment of benign prostatic hyperplasia (BPH).Finasteride has been facilely synthesized from 4-androstene-3, 17-dione by oxidation, ammoniumation, cyanohydrin, dehydration, Ritter reaction, hydrogenation and dehydrogenation. The effects of difference reaction conditions on the yield of product in each step have been investigated and optimal reaction condition has been found. Each product was identified by IR, ~1H NMR spectra.