Synthesis Of Triazole Derivatives Under Microwave Irradiation

In this paper, the synthesis of triazole derivatives under microwave irradiation were studied. First, 3-alkyl/aryl-4-amino-5-mercapto-l,2,4-triazoles were prepared under microwave irradiation, then 3-alkyl/aryl-6-phenyl-l,2,4-triazolo[3,4-b][1,3,4]-thiadiazoles and 5-alkyl-3-mercapto-4-arylmethyleneimine-1,2,4-triazoles were synthesized from 3-alkyl/aryl-4-amino-5-mercapto-1,2,4-triazoles without catalyst under solvent-free microwave-enhanced conditions. This thesis includes three parts work:First: Synthesize of 3-alkyl/aryl-4-amino-5-mercapto-l,2,4-triazoles derivatives from thiocarbohydrazide and acid on the condition of solvent-free, without catalyst, and microwave irradiation.Second: Synthesize of 3-alkyl/ary1-6-pheny1-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazole derivatives from 3-alkyl/ary1-4-amino-5-mercapto-1,2,4-triazoles and benzoyl chloride on the analogy condition.Third: Synthesize of 5-alkyl-3-mercapto-4-arylmethyleneimine-1,2,4-triazoles from 3-alkyl/aryl-4-amino-5-mercapto-1,2,4-triazoles and aromatic aldehyes on the condition as above.In summary, 20 compounds were synthesized under solvent-free, without catalyst, and microwave irradiation condition, 2 compounds among which have not been reported in literatures, all the structures of the compounds are confirmed by elemental analysis, IR, ~1H NMR and mass spectra. Compared with conventional method, microwave method has the advantage of short reaction time and high yields.