Studies On The Troche Which Is Used To Treat Cataract And Age-related Macular Degeneration

In this paper, it was aimed to make a kind of troche with vitamin E, vitamin A, lutein,zeaxanthin, vitamin C and some microelements according to the formula. The antioxidants introche were protected by microcapsule, and the stability of functional ingredients was alsoinvestigated. The troche was able to supply lens and retina with necessary nutrients whentaken periodically, which could postpone, prevent and treat eye illness caused by aging,especially for the cataract and age-related macular degeneration (AMD).In order to protect and disperse the antioxidants evenly, the formula of microcapsulepreparation was discussed as well as the technique of spray drying. The emulsifying capacityof starch octenylsuccinate was studied, and Modistar-9003 was chosen as the wall material ofmicrocapsule. Through orthogonal experiments, the formula and technique conditions werealso optimized as follows: core/wall was 25/30, solids content 30%, homogenizing pressure30MPa and emulsifier/core 20%.The stability and micro-structure of the microcapsule were investigated. By theaccelerated experiment at 60℃ for 90 days, the retention ratio of core materials was 98.2%.The photomicrograph showed that the whole microcapsule's surface was continuous withoutleaks or holes. It indicated that the core material was all embedded by walls, but manyparticles' surface sunk severely. And the condition was improved obviously with the additionof sodium alginate.The stability of microcapsule was affected by the microelements, so the microelementsshould also be encapsulated. EC was chosen as the wall, span-80 as the emulsifier andEC-PE-cyclohexane as the preparation system, and microcapsule of microelements wasformed because of EC's phase separation with temperature's fall. Through the orthogonalexperiments, the optimum ratio of microelements, EC, span-80 and PE was 1.0 : 0.6 : 0.15 :0.25.The formula and technique of troche were discussed, and the analytical method offunctional ingredients was studied. The anticaking agent was added in order to increase thefluidness and resistant agglomeration ability of oil microcapsule. The conditions of HPLCdetermining vitamin E and vitamin A were as follows: mobile phase was methanol-ethylacetate (95:5), flux 1.0 mL/min, detecting wave 325nm for the former 10min and 284nm forlatter 10min, and the column temperature was ambient temperature. The loss of antioxidantsin troche were less than 5% after accelerated experiment for 10 days, which met therequirements of troche.