Study On The Controlled-nanopore Glass Powder To The Biochip Carrier Material

The development of biochip technology has been made great progress entering 21st century. The key of biochip manufacture and analysis is to prepare the carrier material. The preconditions of preparation and analysis of the biochip is how to manufacture the biochip. Furthermore, the key factor of manufacture the biochip is how to prepare to the carrier material. The study of the high-density nanometer porous lattice biochip carrier material has put forward in China under that background. The porous glass powders on basis of phase-separated alkali-borosilicate glasses have been prepared. The heat-treatments of alkali borosilicate glasses of a suitable composition in a temperature range initiate a phase separation. The alkali-rich borate phase is soluble in hot mineral acids, water and alcohols. Therefore the different size and distributing of the porous glass were prepared in this study.In this paper, the controllable aperture glass with pore being dimensional uniformity, interconnect pore, narrow range of pore size is prepared on basis of phase-separated alkali borosilicate glass during the preparation of controlled porosity glass. This article discussed that the preparation method of controllable aperture nanometer porous glass by the sodium borosilicate glass system, characterizing controlled porosity glasses pore size distribution and surface area using scanning electron microscope (SEM) and Brunauer-Emmett-Teller (BET) methods. As a result of the experiments, The results range analysis of pore size in orthogonal experiment were concluded that the compositions, acidic leaching time, heat treatment time, the concentration of HC1 and the heat treatment temperature. Fur more, the results range analysis of surface area in orthogonal experiment were concluded that the compositions, acidic leaching time, heat treatment time, the heat treatment temperature and the concentration of HC1. The two results were the approximately uniformity.At the same time, when the glass system composition should be chose in the three systems phase-separated area coverage, a serial nanometer porous glass was prepared. The Li⁺can promote phase-separated of the Na₂O-B₂O₃-SiO₂porous glass. The promoting phase-separated capacity of the Ti⁴⁺ is bigger than Zr⁴. in this study, the different processing parameters such as the compositions, acidic leaching time,heat treatment time, the heat treatment temperature and the concentration of HC1 of the different pore size distributions (0¹0nm, 10²0nm, 20³0nm, 30⁴0nm, 40⁶0nm, 60⁸0nm, 80¹00nm) were be gotten.The study of the effect on pore size of the nanometer porous glass whose capability in different type biology and chemical samples is very important, furthermore, the carrier material of glass biochip can be provided via the preparation of the nanometer porous glass. The preparation of the high-density nanometer porous lattice biochip carrier material will be got. So it has enormous scientific value to research on biology and the Human Genome project.