Study Of Phase Equilibrium And Reaction For Multi-Compnent Systems

Supercritical antisolvent precipitation of micronizing pharmacy particles and hydration process with reactdistillation to produce glycol and the phase equilibrium of etherifying C5 system are all examined and discussed in this work.According to our investigation, supercritical antisolvent(SAS) precipitation of micronizing pharmacy particles is not studied by other authors in China until now. Solvent and solute in SAS can show different results. How do experiment conditions such as temperature, pressure, preliminary concentration, influence particle size and morphology when micronizing pharmacy by supercritical antisolvent processes.(1) Particle size reduced and sphere morphology is invariable with decreasing temperature(2) Particle size reduced and sphere morphology is invariable with increasing pressure(3) Particle size increased and morphology is variable with increasing preliminary concentration. Pine leaf-like particles can be observed at 10g/L.In addition, particle size reduced with the rate of increasing pressure.To produce glycol a hydration process of water(H2O) and ethylene oxide(EO) by reactdistillation has been studied. Molar reflux, the pressure, the ratio of H2O to EO, the number of perfect plates and the location offeeds have been simulated. The results show as follows.(1) The conversion rate and selectivity increase with increasing molar reflux. The conversion rate has been close to 100% at low molar reflux(R=2), but the selectivity approaches 100% until total reflux.(2) The molar ratio of H2O to EO has gone down to 3:1.(3) When pressure is less than 0.2MPa, the simulation shows errors. When pressure is more than 0.2MPa, the conversion rate goes up with the increasing pressure and the selectivity has reached maximum at 0.5MPa. But 0.8MPa is the optimal value when solubility and energy saving are taken into account.(4) The optimal number of perfect plates is 8.(5) The optimal location of feed plate is the 4th.Properties and phase equilibrium data of etherifying C5 system have been collected. Simulation parameters of NRTL, UNIQUAC and Wilson equation have also been calculated through Aspen Plus.