| The smoke from incomplete combustion of biomass, a kind of fuel widely used in rural area, is one of the main indoor air pollutants. It is reported that COPD, a chronic obstructive pulmonary disease, might have certain relationship with such biomass smoke. Aldehydes could cause chemical stimulation damage in human respiratory tract, or even COPD. Therefore research of aldehyde pollutants in biomass smoke should be an important cut-in point in exploring the cause of COPD.To our knowledge, the main composition of biomass smoke and their biochemical actions have not been studied systematically, therefor the composition of biomass smoke in Shaoguan mountain rural area and the composition of smoke in Guangzhou urban area were analyzed with HPLC-MS and compared firstly, and five aldehydes and a ketone were found, they are formaldehyde, acetaldehyde, benzaldehyde, valeraldehyde, phenylpropyl aldehyde and acetone. Then the amount of three main aldehydes, formaldehyde, acetaldehyde, and benzaldehyde, in biomass smoke and gas smoke were determined. The concentration were 0.75 + 0.29mg/m3, 1.29±0.52mg/m3, 1.47±0.60mg/m3 for the three aldehydes in the biomass smoke and 0.019±0.45mg/m3, 0.016 + 0.3 lmg/m3, 0.027 + 0.26mg/m3 for those in gas smoke respectively, the results showed that the concentrtion of aldehydes in biomass smoke in Shaoguan mountain rural area are obviously higher than that of in Guangzhou urban area (P<0.05). In order to examine the effects of aldehydes in biomass smoke on human body, oxidative damage in mice have been studied. The research results showed that aldehydes could reduce the activity of mice pulmonary SOD and GSH-Px, caused pulmonary tissue lipid peroxidation (P<0.05 vs control group) and increased MDA(P<0.05 vs control group). The research has demonstrated that aldehydes induced oxidative damage in pulmonary tissue of mice, our research has explored primarily the action of aldehydes in biomass smoke in the occurrence of COPD in term of epidemiology, however, how the aldehydes act in the pathogenesis of COPD is to be found in the further research. |
