Studies On Ameliorating The Method Of Preparing Jujubogenin From Ziziphus Spinosa H. And The Chemical Constituents Of Two Compositae Plants

This dissertation deals with two different subjects. One focuses on ameliorating the method of preparing Jujubogenin from Ziziphus spinosa H., and the other one is phytochemical studies of two Compositae plants and the evaluation of their bioactivities.Therefore, this dissertation consists of three chapters. Chapter 1 is a review. In this chapter, Section 1.1 corresponded with the first subject, introduced the components and the bioactivities of Semen Ziziphi spinosa, as well as the present situation of AD therapeutic development and TRB studies development in the latest years. Section 1.2 corresponded with the second subject, introduced the present situation, the development and SAR studies of PAs and sesquiterpenoids.In Chapter 2, Section 2.1 referred to the traditional method of Jujubogenin preparation. Section 2.2 compared the contents of the total saponin between the leaves and the seeds from Ziziphi spinosa, and described the process of extracting saponins from these two parts of the same plant source. Section 2.3 described the preparation of starting material 1.3 (Jujubogenin). The influence of the yield of Jujubogenin by different base utilized in the reaction was discussed.The third chapter referred to the second subject. Section 3.1 described the background of the second subject. Section 3.2 described the structure of nine new eremophilanolides (3.1-3.9), and the stereochemical analysis of the dimer (3.7 and 3.81 formation. Section 3.3 introduced the bioactivities of the compounds. And the result of the experiments in Section 3.2 and Section 3.3 were concluded finally.