Synthesis And Characterization Of The Mannose Thio-trisaccharide As Anti-HIV Agent Targeting DC-SIGN | Posted on:2005-07-24 | Degree:Master | Type:Thesis | Country:China | Candidate:D Jie | Full Text:PDF | GTID:2121360125469270 | Subject:Polymer Chemistry and Physics | Abstract/Summary: | PDF Full Text Request | Dendritic cell specific intracellular adhesion molecule–3 (ICAM-3) grabbing nonintegrin (DC-SIGN) can bind to the HIV surface protein gp120. It has been shown to be largely responsible for the ability of dendritic cells to efficiently capture and present HIV-1 to receptor-positive cells. DC-SIGNR, a receptor that is 77% identical in sequence to DC-SIGN also can bind HIV. Crystal structure of DC-SIGN(R) with pentasaccharide complex has been solved. Based on the crystal structure of DC-SIGN/DC-SIGNR and considering the saccharide stability in physical condition, We designed a thio- trisaccharide as an anti-HIV agent for the AIDS chemotherapy and prevention. The synthesis work has been accomplished in good yield. The assay of its anti-HIV activity is in progress and will be reported in near future.
| Keywords/Search Tags: | DC-SIGN, Mannose, HIV, Oligosaccharide, Synthesis, Characterization | PDF Full Text Request | Related items |
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