Study On Synthesis And Bioactivity Of Compounds Of Three Kinds Momocyclic Monoterpeiods And Oxime Ether Containing

In order to search novel derivatives which had higher biologicalactivity and green concept in environmental protection, we designed and synthesized three series of new compounds according to the principle of model natural active material and linking inferior structure. First of all,we synthesized their oximes of three kinds of monocyclic monoterpenoids Secondly, oximes reacted with halogenoalkanes to make oxime ethers. The structures of the target compounds had been confirmed by FT-IR, MS, 1HNMR, and so on. And their structures were as follows:In the course of the synthesis of target compounds, we found that the polor aprotic solvents (DMSO,DMF) were particularly effective in enhancing the rate of the reactivity, but had disadvantages in terms of product workup and purification. We also found that when the solvents such as toluene and phase transfer catalysts were used in the synthesis of target compounds, good results could be obtained. Reactive temperature ranged from the room temperature to 65 C and productivity ranged 21.2% to 83.25% according to different reactive materials, oxime ethes were afforded by Chromatography on silica gel with light petroleum and ethyl acetate as eluent which ranged from 10:l(v:v) to 30:l(v:v).The preliminary fungicidal and insecticidal activities of part target compounds were determined on F.graminearum, Phytophthoracapsici, Maganporthe grisea,Botrytis cinerea,etc and Leucania Separata,Aphid, Kock,kalrenbach. The results indicated that compound II b exhibited rather high activity (A grade) to Kock and 95.18% mortality against it. Compounds II d and Hid revealed activities of B grade to Kalrenbach and Kock.