Study On The Synthesis And Properties Of Bisquats And Thiadiazoles

Six compounds of bis(quaternary ammonium), 1,2-bis(N,N-dimethyl-N-dodecylammonium bromide-N-methylene) benzene (1,2-DBnQA), 1,3-bis(N,N-dimethyl-N-dodecyl ammonium bromide-N-methylene) benzene (1,3-DBnQA),1,4-bis(N,N-dimethyl-N-dodecyl ammonium bromide-N-methylene)benzene(1,4-DBnQA), 1,4-bis(N,N-dimethyl-N-dodecyl ammonium bromide)butane(1,4-DBuQA), 1,4-bis(N,N-dimethyl-N-dodecyl ammonium bromide)-2-butylene(1,4-DBeQA) and 1,4-bis(N,N-dimethyl-N-dodecyl ammonium bromide)-2-butyne(1,4-DByQA) were synthesized by the reaction between dimethyldodecylamine andvaried dibromides. The latter two are new compounds. All of them have beendetermined by IR and H NMR. The bioactivities of these quaternary ammonium 1Gemini surfactants have been determined. They all have the higher antibacterialproperties than the mono(quaternary ammonium). We also find that the bioactivitiesincrease with the decrease of the saturation of the linkers. The compounds of 2,5-dimercapto-1,3,4-thiadiazole derivatives,2,5-bis(methylthio)-1,3,4-thiadizole (DMTZ), 2,5-bis(ethylthio)-1,3,4-thiadizole(DETZ), 2,5-bis(benzylthio)-1,3,4-thiadizole (DBTZ), 1,4-bis(5-mercapto-1,3,4-thiadizole-2-thio)-2-butene (BeTZ), 4,16- dioxa-1,7,13,19-tetrathia[7.7]-(2,5)-1,3,4-thiadiazolophane (DATZ), cagelike thiadiazole derivative (TBTZ) were synthesizedby the reaction between 2,5-dimercapto-1,3,4-thiadiazole and varied halides. BeTZand TBTZ are new compounds. The structures of them have been determined by IR,1H NMR and element analysis. The crystal structure of {[Ag2(DMTZ)4](ClO4)2}∞ wasdetermined by IR and X-ray diffraction. It was found that the Ag ions coordinate withS and N from different thiadiazole.