Study On Antimicrobial Rare Earth Complexes And Their Nanocomposite Antimicrobial Materials

Rare earth complexes have a good antimicrobial properties, which is manifested by the huge number of publications ranging from pharmaceutical chemistry to biochemical relevant studies, it can be used to synthesize novel antimicrobial agents and materials. Based on detailed investigation of a great deal of related literatures, the recent progress in the field of rare earth antimicrobial complexes as well as antimicrobial agents and materials was reviewed. Meanwhile, a great deal work have been done on the synthesis of antimicrobial rare earth complexes and nanocomposite antimicrobial materials doped rare earth complexes. The main achievements in my work are summarized as follows:1. Eight salicylic complexes of rare earth and eight rare earth ternary complexes were successfully synthesized by solid-state reaction at low temperature. The complexes were characterized by EA UV, IR, XRD and TG-DTA. Moreover, the antimicrobial properties of the sample were tested by plant method and MIC. The antimicrobial mechanism of rare earth complexes and the factor which affect the antimicrobial properties of the sample were also primiarily discussed on the base of experiment. The results show that the addition of the 8-hydroxyquinoline help the reaction happen and complete, but also increase antimicrobial abilities of the complexes.2. Novel organic-inorganic nanocomposite antimicrobial materials doped rare earth complexes were in-situ synthesized by sol-gel process of silicon tetraethoxide in the presence of surfactant. The samples were characterized by IR XRD TEM AFM and TG-DTA, and the roles of surfactant in the forming of sample were also discussed, and the results indicated that the modified sample had a regular shape, uniform size as well as good disperse in common solvents.3. The factors which affect antimicrobial properties of the sample such as kinds of rare earth complexes, the amount of doped were discussed. Moreover, the effects of sol-gel process on the heat stability and antimicrobial properties of the sample were also discussed. The results displayed that the antimicrobial activities had great relation to the variety and proportion of the doped rare earth complexes. However, in the same conditions, the size of the sample had a lower effect on antimicrobial activities of the sample. In the end, forming mechanism of the uniform particles and the role of the surfactant were also discussed.At last, the whole work has been summarized and the prospective following these work in the present thesis are suggested.