Synthetic And Technological Study Of Zeatin And Several Intermediates Of Fine Chemistry

The first part. As one of phytohormones, trans-zeatin is the first one of cytokinins that is separated from plant. It is basic material that plants need in the course of growth. In all of cytokinins, the trans-zeatin is the most active. Because there is little zeatin in the plant, it's difficult to abstract it from nature to supply the demands. So it is urgent to exploit a synthetic method for current demands.So far there are dozens of methods to synthesize trans-zeatin, but none of which is effective with good yield and purity. In this work, we selected two synthetic strategies based on the survey of the literatures. After careful studies, we obtained a good synthetic method, with which kg scale product can be provided with 99% purity.The second part. Now days, the trend of development of chemical industry in the world is shifting to fine chemistry, and the structure of chemical industry is changing. In the past several decades, there is quiet great advancement in every field of fine chemistry. However the progress in our country is relatively slow. So, it is very important to study applied chemistry which can make science and technology into productivity.Substituted diphenoxide ethane is used as additive in the course of synthesizing macromolecule material. Since there are some disadvantages in former method, such as poor yields and complex manipulation, great demands at the international market can not be satisfied entirely. Based on theory of the neighboring group participating and theory of phase transfer catalysis, we have improved the yield and simplified oparetion.o-Trifluoromethylbenzoyl chloride, an important medical intermediate, have been synthesized with o-trifluoromethyl chlorobenzene as the starting material through three-step reactions including the preparation of Grignard reagent, the subsequent addition with CO2, and the carbonyl chloride reaction with SOCl2. Several improvements have been done in this paper as follows: (I) screening out the optimal assistant reagent-CHsCHiBr; (II) replacing dry-ice with CO2; (III) solving the problem of the recycle of THF; (IV) facilitating the preparation ofo-trifluoromethylbenzoyl chloride. With the above improvements, the synthetic conditions of o-trifluoromethylbenzoyl chloride are very favorable to industrial production.