Study On The Selective Synthesis Of α-arylpropanic Acids

α-arylpropanic acids have been proved to be of great use on some diseases－rheumatism and rheumatoid arthritis for its highly effect on inflammation,ache and fever as non-steroidal anti-inflammatory agent .they are widely used as antipyrotic, anodyne and acetanilide.Because it was investigated that most of (R)-α-arylpropanic acids have much negative effect on stomach, (S)- α-arylpropanic acids ,which chem- -ists are effort to synthesize pure optically active isomer ,are popular with patients.The dissertation optimizes the condition of Friedel-Crafts reaction,using nitro- -methane and triethylamine instead of nitrobenzene and pyridine, respectively .The innovation of the paper is that Baker's Yeast has been used to reduce a series of intermediate products of α-arylpropanic acids such as ethyl α-methylenebenzeneacetate , α-methylenebenzeneacetonitrile and α-methylenebenzeneacetic acid.The reduced products are analysed by GC-MS and given a rational explaination.Furthermore,serval ways to synthesizing intermediate products have been investigated , and a simple route to synthesizing α-methylenebenzeneacetic acid come through carbenes was been found.Most of the intermediate products have been characterized by IR and 1H-NMR.