Synthesis Of Levosimendan And Its Analogs And Research Of Their Activities In Anti-CHF

As one of the severe diseases in clinic, Congestive Heart Failure (CHF)is catching more and more people's attention. The pharmacotherapy of CHF has experienced a long period of evolvement. Inotrops, vasodilators, diureticsand β -blockers are main kinds of drugs for CHF. Levosimendan is one ofthe new drugs available in market for treating CHF which belongs to calcium sensitisers. The results of clinical assessment showed that levosimendan was safe and effective which could improve the prognosis of the patients and kept normal blood kinetics.By improving the reported synthetic route, levosimendan was synthesized from acetanilide via eight steps of reaction. Then with levosimendan as a leading compound, 11 unreported compounds were designed and synthesized by structure modification of levosimendan, all with optic activity. The structures of the target compounds were identified by elemental analysis, MS, IR and 'H-NMR.The bio-activity of the target compounds were tested in blood pressure experiment, with levosimendan as a contrasting group. Results showed that the target compounds were effective to CHF by dilating blood vessel.