Studies On Synthesis And Biological Activities Of Phosphoryl And Aroyl Silatranes

Silatranes are organosilicon compounds having specific molecular structure and obvious biological activity. Their properties, synthetic methods and reaction conditions are greatly related to the substituents on silicon atom. In this thesis, Y -aminopropyl silatrane was synthesized by tranesterification of trialkoxysilanes with triethanolamine. Six dialkoxyl phosphoryl aminopropyl silatranes, six alkoxyl thiophosphoryl aminopropyl silatranes and eleven substituted aroyl aminopropyl silatranes were synthesized by the functional group transformation reaction on silatranes. The structures of the title compounds were confirmed by elementary analysis, IR, HNMR and MS measurements, and the results show that their structures are accorded with the expected ones. Their physical, chemical properties and spectroscopic characteristics were investigated systematically. The structural formuals of the title compounds are as follows respectively: (I): dialkoxyl phosphoryl aminopropyl silatranes(II): alkoxyl thiophosphoryl aminopropyl silatranes(III): substituted aroyl aminopropyl silatranesDuring the experiments, the functional group transformation reaction is oftenaccompanied by silatrane ring cleavage, which leads further to some polymer formation. In order to avoid the side reactions, the control of reaction conditions is rather important. We find an alkaline substance such as triethylamine should be added to remove the acidic by-product and appropriate solvent should be chosen accurately.The preliminary bioassay of antibacterial activity was determined, and the results indicated that some of the compounds exhibited biological activity to some extent. Especially Ila lid, Illk has good antibacterial activity.