Research On The Synthesis Of Heterocyclic Derivatives Of Guanidine

This paper is mainly about the synthesis of heterocyclic derivatives of guanidine. The trait of its synthesis by compounding l-ethyl-2-cyanimino imidazolidine and its intermediate N-ethylethylenediamine was studied. 1-ethyl -2-cyaniminoimidazolidine has been found to inhibit the reabsorption of glucose, lower the rate of gluconeogenesis and has a potentiating action on insulin in the utilization of glucose by muscular tissue. N-ethylethylenediamine is one of the most import important intermidiates in the preparation of the heterocylic derivatives of guanidine.After consulting several pieces of patents and literatures, ethanolamine and acrylamide were choosed as raw material respectively. First ethanolamine via neutralisation, hydrochlorination and animation with ethylamine, to prepare N-ethylethylenediamine, the yield is 59.2%. Second, acrylamide was used as raw material , via a , P -unsaturated addition with ethylamine, Hofmann reaction in sodium hypochlorite solvents to achieve N-ethylethylenediamine( this is a new way ), the yield is 58.4%. Then 1-ethyl -2-cyanimino imidazolidine can be prepared by reacting N-ethylethylamine and N-cyanimino -dithiocarbonic acid dimethyl ester, the yield is 74%. All compounds that have been prepared in this study have been identified through instrument analysis.