Synthesis And Structure Study Of Thiazolidinone Derivatives

The thesis is mainly consists of five chapters. Chapter one is mainly about the synthesis and application research of 4-thiazolidinones in the recent years; Chapter two is mainly about the systhesis of N-subtituted thioureas in the task-specific ionic liquids. Chapter three is about the systhesis of 3-alkyl-2-benzoylimino-4-thiazol-idinones and their structure study; Chapter four is about the study of the tautomerism and structure of 2-alkylimino-4-thiazolidinones.Chapter one made a minireview of the progress about the sythesis and applications of 4-thiazolidinones according to different raw material, solvent, catalyst and so on in the recent ten years.Chapter two firstly reviewed the progress about the sythesis and applications of N-subsitituted thioureas in the decade. Secondly, N-substituted thioureas were synthesized efficiently by two-step reaction:(1) Acyl chlorides and amides reacted in functional ionic liquid [emim]SCN rapidly at room temperature to form N-benzoyl-N'-tert-butylthioureas in high yields. (2)N-benzoyl-N'-tert-butylthio-ureas were hydrolyzed in NaOH/H2O/EtOH to yield N-substituted thioureas with almost 100% yield. We provided an efficient, green and practical method of the synthesis of thioureas.Chapter three described the synthesis of the 3-alkyl-2-benzoylimino-4-thiazolidinones and the analysis about the structure of them. We found an efficient and green method of the synthesis of 4-thiazolidinones.Chapter four explored the relation of thiazolidinones and their isomerism with ionic liquid,raw material,the react condition and so on. Firstly, N-tert-butyl thioureas react with 2-halo acetic acid in different solvent mediums. Then according to the studies, we synthesized 2-alkylimino-4-thiazolidinones.Last chapter is about the 1H NMR and IR and so on of 4-thiazolidinones.