Study On The Supramolecular Systems Of Amino Porphyrins And It's Derivatives With Cyclodetrins

Porphyrin and it's metal complexes are the requisite substances of cytochrome, hemachrome, chlorophyll, etc, which play significant roles in biological processes. The research of Cyclodextrin-Porphyrin supramolecular system had been widely used in the field of blot analysis of genes, drug controlled releasing, chiral recognition, molecular switches and analog enzyme. Porphyrin-CD's inclusion mechanism is perfected daily, and the field's development is very contributing to the progress of life science and pharmaceutical research.In this thesis, NTPPH2 and ATPPH2 were synthesized and characterized. And the supramolecular system of the porphyrins withα-CD,β-CD andγ-CD were studied in detail by means of fluorescence spectroscopy and UV-visible spectrophotometry. Determined the formation constants of the six supramolecular systems.We discussed the effect of electron-donating group and electron-withdrawing group on inclusion. The results show that the electron-donating group is more conducive to the formation of inclusion.We also synthesized BATPPH2 and its Zn complexes, verified their structure. Studied on the supramolecular system of BATPPH2 and BATPPZn with different cavity size of cyclodextrin by fluorescence spectroscopy, UV-vis, and 1H NMR. Investigated the effect that Zn2+ of the porphyrin ring plays on the process of inclusion. The results show that the size of BATPPH2 and BATPPZn matches with the cavity size ofγ-CD best; Zn2+ strongly impeded the process of inclusion, but hardly impact the ratio of complex.A series of amino porphyrin with different substituted position (Cis-DADPPH2, Trans-DADPPH2, Tri-APPH2 and TAPPH2) were synthesized, and their structure were confirmed. Studied on their supramolecular system with different cyclodextrins, and researched into the influence of position and the number of amino groups on inclusion, try to find the law and explore its inclusion mechanism. As this series are very systematic, they will have considerably theoretical significance. All of the research have not been reported.