Recognition Of Mammal Chromosome Breakpoint Region And Analysis Of Related Gene

The persistence of large blocks of homologous synteny and a high frequency of breakpoint reuse are distinctive features of mammalian chromosomes that are not well understood in evolutionary terms. To gain a better understanding of the evolutionary forces that affect genome architecture, synteny relationships among 12 amniotes (human, chimp, orangutan,rhesus,mouse,rat, cattle, pig,dog, horse,opossum, and chicken) were compared at 500 human-Kbp resolution. Homologous synteny blocks (HSBs; N = 2092) and chromosome evolutionary breakpoint regions (EBRs; N = 1041) were identified from pairwise comparisons of all genomes. Gene function analysis of msHSBs >3 human-Mbp and EBRs <1 Mbp demonstrated that msHSBs are significantly enriched for genes involved in development of the central nervous , signal transduction and other organ systems, whereas EBRs are enriched for genes associated with adaptive functions and response.