Study On Molecular Bilogical Systems Based On The Finite State Machine

The Central Dogma of Molecular Biology is an important achievement in biology after the finding of the double helix structure of DNA. It illuminates the transition direction of the genetic information. The Molecular Biology is a scientific which researches the structure and function of the biological in molecular level. After 1950s, the Molecular Biology has become the hot research field; especially the study of DNA is an important field in molecular biology. However, most of the existing results are get by biochemistry laboratory. Along with the development of computer and information technology, some advanced control method has been used in this filed. But, it has no mature theoretical modesl, and the error of the DNA computation is high.The protein is the material basis of life activities. The function of protein is closely related to its structure, so if we know the structure of a protein we can realize its function. Recently, the experimental method is also the main method to get the protein structure. But this method is slowly. So, getting the protein structure by theory is a better choice.In Chapter 2, the model of the polarity of amino acid based on FSM is given. FSM is a method which is powerful in discrete event dynamic systems. The examples illustrate the main results at the end of this chapter. An algorithm of gene mutations based on FSM is given in Chapter 3. According to the change of the genetic structure, the gene mutation can be divided into substitutions, remove mutations, missing mutations and insertional mutations. The example and analysis in two equal length DNA and two different length DNA are given. As the same time, we can calculate the rate of the gene mutation. In chapter 4, the FSM model of the super-secondary protein structure is given. The super-secondary protein structure is a structure which is between the secondary and structure domain. The protein can be divided into allαprotein, allβprotein,α/βprotein andα+βprotein. We discuss the algorithm of the four structures, as the same time, we can know the content of theαhelix andβfold. Finally, a conclusion of the dissertation and some future research topics in the field are given in Chapter 5.