An Extension And Test For Gene-Gene Interaction Based On Linkage Disequilibrium

Gene-gene interaction is a very important but complex concept.Traditionally,gene-gene interaction is defined as a statistical deviance from the additive effects of single genes,which is often referred to as "statistical interaction" between genes.The maximal disadvantage of statistical interaction is lacking of clear biological interpretation of gene-gene interaction,and the power to detect gene-gene interaction is low.Zhao et al.(2006) put forward a new definition for interaction of two unlinked loci,which can be interpreted in biology.Homoplastically,we will put forward a new definition for interaction of two linked loci,and we will use homogeneity test gained by Yin et al.(2007).In Genome-wide association studies,we focus on two-stage-analyses: analyses in which we only test for interactions between singal nucleotide polymorphisms that shows some marginal effect.