Modeling FGFR-induced MAPK Signal Pathway

Intracellular signal transduction networks can receive and process information to the mediation of cell physiological activities. It is an important physiological function of cells. They are closely related with cell proliferation, differentiation, apoptosis and other physical activities.Signaling pathway disorder will lead directly to the tumor and the incidence of cancer. Mitogen-activated protein kinase signaling pathway (MAPK) - induced cell response is an important signal system prevalent in a variety of species. MAPK cascade pathway can be activated by many growth factors, participating in a variety of physiological reactions in cells.Basic fibroblast growth factor FGF-2 (also known as bFGF) is the potential of angiogenesis factor and the incidence of diseases related to the normal wound healing and the development of the organization. FGF-2 receptor (FGFR) is the high-affinity receptor, after binding to bFGF, phosphorylation and dimerization itself, ultimately resulted in activation of multiple signaling pathway, such as Ras/MAPK, JAK, Phospholipase Cγ(PLC-γ) signaling pathway.FGFR-induced MAPK signaling pathway plays an important role in tumor growth and angiogenesis, regulating chemotactic responses, cell division. And it also regulates the development of nerve cells and fibroblasts. Currently, few research on how the regulatory factors to mediate FGFR-induced MAPK signaling network Cell signaling networks are very complicated in terms of organization and regulation.Researchers generally combine experimental results and fitting data aided by mathematical methods to develop signal networks models, which insight into the comprehensive mechanisms involved in the signal transductions.The thesis will do research on the MAPK pathway through computer simulation, modeling FGFR MAPK signal transduction pathway on the basis of the analysis of experimental data. Combining simulation results with experimental data, we research MAPK signal transduction pathway, focusing on the study of the Ras, FRS2, MKP-1, PP2A and other regulatory factors in the regulation of the MAPK pathway.