The Research Of Neural Plasticity's Phosphorylation Modeal

Neural Plasticity is a theory that neural cell can change its ability and state when the outside environment is changed. Neural Plasticity is mainly related to the self change of the neural system under the influence of outside factor and condition. The research of neural plasticity is very important to the development of modern medicine,such as the recovery of brain trauma.LTP(Long-term potentiation)and LTD(long-term depression)are two major forms of Neural Plasticity. Under the influence of stimulating signal, if the potential of cell membrane undergo a long term synaptic potentiation, we call it LTP. And if the potential of cell membrane undergo a long term synaptic depression, we call it LTD.NMDA receptor and AMPA receptor are two ion channel located in membrane. AMPA receptor can change the membrane potential and NMDA receptor is the major source of Ca 2+ . There are lots of enzyme exist in the neural cell, such as PKA,PKC,CaMKâ…¡and so on. Their activity are regulated by the concentration of Ca 2+ . These enzymes can phosphorylate and dephosphorylate ion channel on the membrane to change the conduction of ion channel , play a very important role in Plasticity . Under this background. I use mathematical model to study Neural Plasticity, in order to further understand the mechanism of Neural Plasticity. The mainly scientific works are as follows : Considering that there are two phosphorylation site change the conduction rate of AMPA receptor, and 3 enzymes can phosphorylate and dephosphorylate AMPA receptor. I design a mathematical model to relate enzymes with AMPA receptor of different phosphorylation state. Results demonstrate the relationship between AMPA receptor's conduction and the concentration of Ca 2+ ,successfully simulate the LTP curve. The results accord with Neural Plasticity theory. And explains the relationship between Glu receptor's phosphorylation and Neural Plasticity.